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Semantic Scholar · Article (Multiple Sclerosis and Related Disorders)
Methylphenidate may improve mental fatigue in individuals with multiple sclerosis: A pilot clinical trial.
Attribution
This is the abstract and citation. Full text lives at Semantic Scholar — we link out rather than host. All credit to the authors and Multiple Sclerosis and Related Disorders.
Abstract
Verbatim from Semantic Scholar. Not paraphrased, not summarized.
BACKGROUND Fatigue is the most common symptom in multiple sclerosis (MS), previously attributed to dopamine imbalance. Evidence suggests that methylphenidate, a psychostimulant that increases striatal and prefrontal dopamine levels, is effective in reducing fatigue in various disorders. However, its effect on state vs. trait mental fatigue in MS is yet to be examined. METHODS This pilot study investigates the efficacy of methylphenidate on decreasing self-reported mental fatigue in 12 individuals with MS in a double-blind, placebo-controlled, cross-over randomized clinical trial. RESULTS Our results show that "state", but not "trait" MS-related fatigue, was reduced after 4 weeks of methylphenidate administration as compared to placebo.
Authors
- J. Y. Natsheh
- J. DeLuca
- S. Costa
- N. Chiaravalloti
- E. Dobryakova
Keywords
- Medicine
Citation: J. Y. Natsheh, J. DeLuca, S. Costa , et al. (2021). Methylphenidate may improve mental fatigue in individuals with multiple sclerosis: A pilot clinical trial.. Multiple Sclerosis and Related Disorders. Semantic Scholar ID 2025d28379f3340f250bef8f95344a917b5ac300. https://doi.org/10.1016/j.msard.2021.103273 ↗