Research papers

Adaptive conjunctive cognitive training (ACCT) in virtual reality for chronic stroke patients: a randomized controlled pilot trial

Current evidence for the effectiveness of post-stroke cognitive rehabilitation is weak, possibly due to two reasons. First, patients typically express cognitive deficits in several domains.

Routine opioid outcome monitoring in community pharmacy: Outcomes from an open-label single-arm implementation-effectiveness pilot study.

BACKGROUND In response to rising harms with prescription opioids, recent attention has focused on how to better utilise community pharmacists to monitor outcomes with opioid medicines.

Arc Tracking Control in Insulation Systems for Aeronautic Applications: Challenges, Opportunities, and Research Needs

Next generation aircrafts will use more electrical power to reduce weight, fuel consumption, system complexity and greenhouse gas emissions.

Changes in leg cycling muscle synergies after training augmented by functional electrical stimulation in subacute stroke survivors: a pilot study

Muscle synergies analysis can provide a deep understanding of motor impairment after stroke and of changes after rehabilitation. In this study, the neuro-mechanical analysis of leg cycling was used to longitudinally inve…

First Steps Toward Positive Behavior Support in the Netherlands: A Pilot Study Exploring the Effectiveness of a Training for Staff

Despite the effectiveness of positive behavior support (PBS) in reducing challenging behaviors, the availability of PBS for individuals with intellectual disabilities is limited in many countries including the Netherland…

Compassion Meditation Training for Hospital Chaplain Residents: A Pilot Study

Abstract This study examines the effectiveness of incorporating compassion meditation training into a clinical pastoral education (CPE) curriculum to enhance compassion satisfaction and reduce burnout among hospital chap…

Effect of respiratory muscle training on dysphagia in stroke patients—A retrospective pilot study

Dysphagia is prevalent with cerebrovascular accidents and contributes to the burden of disease and mortality. Strengthening dysfunctional swallow muscles through respiratory muscle training (RMT) has proven effective in …

EFFECTIVENESS OF ROBOTIC BALANCE TRAINING ON POSTURAL INSTABILITY IN PATIENTS WITH MILD PARKINSON’S DISEASE: A PILOT, SINGLE-BLIND, RANDOMIZED CONTROLLED TRIAL

Objective To examine whether tailored robotic platform training could improve postural stability compared with conventional balance treatment in patients with mild Parkinson’s disease.

Effectiveness and feasibility of a mindful leadership course for medical specialists: a pilot study

Medical specialists experience high levels of stress. This has an impact on their well-being, but also on quality of their leadership.

Early-Integrated Palliative home care and standard care for end-stage COPD (EPIC): A Phase II pilot RCT testing feasibility, acceptability and effectiveness.

BACKGROUND While early-integrated palliative home care (PHC) is believed to be beneficial for COPD patients, trials testing this hypothesis are rare and show inconclusive results.

The Effectiveness of Charge Nurse Training on Leadership Style and Resiliency.

OBJECTIVE The study objective was to investigate a charge nurse pilot training program as an effective, evidence-based training modality to improve leadership style and resiliency.

Fatigue management for adults living with HIV: A randomized controlled pilot study.

Fatigue is a prevalent symptom for adults living with HIV infection. The purpose of this randomized clinical trial was to pilot test a behavioral-educational intervention to reduce fatigue.

Effectiveness of an Evidence-Based Amputee Rehabilitation (EBAR) Program: A Pilot Randomized Controlled Trial.

BACKGROUND Despite the prevalence of lower limb amputation (LLA) only a small percentage of people with LLA actually receive physical therapy post amputation and are rehabilitated to their full potential level of functio…

Compliance, adherence and effectiveness of a community-based pre-operative exercise programme: a pilot study

BackgroundPre-operative exercise training improves HR components of fitness and HRQoL following hospital-based programmes.ObjectiveTo assess compliance and adherence of a pragmatic community-based preoperative exercise p…

Calling Out MS Fatigue: Feasibility and Preliminary Effects of a Pilot Randomized Telephone-Delivered Exercise Intervention for Multiple Sclerosis Fatigue

Supplemental Digital Content is Available in the Text. Background and Purpose: Fatigue is a common and debilitating symptom of multiple sclerosis (MS).

The feasibility of Pilates to improve symptoms of anxiety, depression, and fatigue among people with Multiple Sclerosis: An eight-week randomized controlled pilot trial

Abstract Objective Evidence supports benefits of exercise for mental health among people with Multiple Sclerosis (PwMS). However, non-traditional exercise modes like Pilates remain understudied.

The Effectiveness Of Radial Extracorporeal Shock Wave Therapy In Patients With Chronic Low Back Pain: A Prospective, Randomized, Single-Blinded Pilot Study

Purpose This prospective, randomized and single-blinded study assesses the influence of radial extracorporeal shock wave therapy (rESWT) in patients with low back pain (LBP).

Internet-Assisted Cognitive Behavioral Intervention for Targeted Therapy–Related Fatigue in Chronic Myeloid Leukemia: Results From a Pilot Randomized Trial

Fatigue is a common and disabling side effect of targeted therapies such as tyrosine kinase inhibitors (TKIs) used to treat chronic myeloid leukemia (CML).

Comparison of the Effectiveness of High-Intensity Interval Training in Hypoxia and Normoxia in Healthy Male Volunteers: A Pilot Study

Aims The study investigated the effect of high-intensity interval training in hypoxia and normoxia on serum concentrations of proangiogenic factors, nitric oxide, and inflammatory responses in healthy male volunteers.

Effects of a Mixed Reality-based Cognitive Training System Compared to a Conventional Computer-assisted Cognitive Training System on Mild Cognitive Impairment: A Pilot Study

Background: Mixed reality (MR) technology, which combines the best features of augmented reality and virtual reality, has recently emerged as a promising tool in cognitive rehabilitation therapy.

Determining the feasibility and effectiveness of brief online mindfulness training for rural medical students: a pilot study

We sought to determine the feasibility and effectiveness of a mindfulness training program, delivered online to medical students at a Rural Clinical School.

Pain Management in Nursing Home Residents: Findings from a Pilot Effectiveness‐Implementation Study

To evaluate the effectiveness and implementation of a multilevel pain management intervention in nursing homes (NHs) comprising a pain management guideline, care worker training, and pain champions.

Diurnal Cortisol Levels and Subjective Ratings of Effort and Fatigue in Adult Cochlear Implant Users: A Pilot Study

Purpose There is a growing body of literature that suggests a linkage between impaired auditory function, increased listening effort, and fatigue in children and adults with hearing loss.

sEMG-Based Detection of Compensation Caused by Fatigue During Rehabilitation Therapy: A Pilot Study

To stimulate neuroplasticity, the stroke patient often receives repetitive and high load robotic rehabilitation therapy. Given their impaired motor function, the patients are prone to muscle fatigue.

Exploring the Impact of a Mobile Health Solution for Postpartum Pelvic Floor Muscle Training: Pilot Randomized Controlled Feasibility Study

Background The postpartum period is a vulnerable time for the pelvic floor. Early implementation of pelvic floor muscle exercises, appropriately termed as pelvic floor muscle training (PFMT), in the postpartum period has…

Description of a multifaceted intervention programme for fatigue after acquired brain injury: a pilot study

Pilot results suggest that multifaceted group-based interventions may have the potential to alleviate symptoms of fatigue, anxiety and sleepiness after ABI.

Lipid profile is associated with decreased fatigue in individuals with progressive multiple sclerosis following a diet-based intervention: Results from a pilot study

Purpose To investigate associations between lipid profiles and fatigue in a cohort of progressive multiple sclerosis (MS) patients on a diet-based multimodal intervention.

Leading article: What has an Airbus A380 Captain got to do with OMFS? Lessons from aviation to improve patient safety.

The understanding of why air accidents occur and all the factors involved with them has been a strong and constantly evolving driver for improving flight safety.

Cognitive behavioural therapy for post-stroke fatigue and sleep disturbance: a pilot randomised controlled trial with blind assessment

Overall, CBT is a promising treatment for improving post-stroke fatigue, sleep quality and depression and warrant extension to a phase III clinical trial.

Effectiveness of high intensity interval training supplemented with peripheral and inspiratory resistance training in chronic heart failure: a pilot study

Abstract Background: Cardiac rehabilitation (CR) is an evidence-based therapy in chronic heart failure (CHF). There is still debate about the optimal training protocol in CHF.

A Prospective Pilot Randomized Study: Electroacupuncture vs. Sham Procedure for the Treatment of Fatigue in Patients With Quiescent Inflammatory Bowel Disease.

BACKGROUND Fatigue is a common symptom in patients with inflammatory bowel disease (IBD), and it often persists despite clinical remission.

Cognitive Behavior Therapy for Persistent Severe Fatigue in Childhood Cancer Survivors: A Pilot Study

Objectives: Fatigue is a common and disabling late effect in childhood cancer survivors (CCS). In this pilot study, the effectiveness of cognitive behavior therapy (CBT) in CCS with persistent and severe fatigue was retr…

Speech Analysis for Fatigue and Sleepiness Detection of a Pilot.

BACKGROUND: Mental fatigue and sleepiness are well recognized determinants of human-error related accidents and incidents in aviation.

Fatigue resistance of monolithic lithium disilicate occlusal veneers: a pilot study

A threshold value of 0.8 mm may represent an acceptable compromise between fatigue resistance and tooth reduction in LD molar veneer restorations using a simplified fatigue testing machine.

Caregivers’ burden and fatigue during and after patients’ treatment with concomitant chemoradiotherapy for locally advanced head and neck cancer: a prospective, observational pilot study

PurposeKnowledge of caregivers’ burden and fatigue before and after patients’ treatment for locally advanced head and neck cancer is scarce.

Effectiveness of a community based out-of-hospital cardiac arrest (OHCA) interventional bundle: Results of a pilot study.

BACKGROUND 70% of Out-of-hospital cardiac arrests (OHCA) in Singapore occur in residential areas, and are associated with poorer outcomes.

Fatigue in primary Sjögren’s syndrome: A proteomic pilot study of cerebrospinal fluid

Objectives: Fatigue is a frequent and often disabling phenomenon that occurs in patients with chronic inflammatory and immunological diseases, and the underlying biological mechanisms are largely unknown.

Randomized controlled trial: a pilot study of a psychoeducational intervention for fatigue in patients with quiescent inflammatory bowel disease

Introduction: Fatigue is a frequent, debilitating symptom of inflammatory bowel disease (IBD). Despite this, studies report dissatisfaction among IBD patients regarding how little attention is given to fatigue-related is…

A Pilot Exploratory Proteomics Investigation of Mental Fatigue and Mental Energy.

A proteomics experiment of three samples and also three matched controls found no particular protein that has significant changes in fatigue sample upon treatment, but did note a potential association between changes in …

Perceived Fatigue in Spinal Muscular Atrophy: A Pilot Study

Background: Fatigue is a common complaint in spinal muscular atrophy (SMA). Fatigability is well described in ambulatory SMA but the relationship to perceived fatigue has not been evaluated.

Caring for the caregivers: Evaluation of the effect of an eight-week pilot mindful self-compassion (MSC) training program on nurses’ compassion fatigue and resilience

Background Nurses vicariously exposed to the suffering of those in their care are at risk of compassion fatigue. Emerging research suggests that self-compassion interventions may provide protective factors and enhance re…

A randomized pilot study of music therapy in the form of patient-preferred live music on fatigue, energy and pain in hospitalized adult oncology patients on a blood and marrow transplant unit

ABSTRACT Introduction There is a lack of randomized research measuring how music therapy might influence fatigue in oncology patients.

Hoop training: a pilot study assessing the effectiveness of a multisensory approach to treatment of body image disturbance in anorexia nervosa

PurposeWe tested in a pilot study a new intervention for body image disturbance in anorexia nervosa (AN). Unlike common treatment approaches our hoop training targeted not only cognitive-emotional and visual aspects of b…

Cardiac Inflight Incapacitations of U.S. Airline Pilots: 1995-2015.

INTRODUCTION Inflight medical incapacitations are rare events that can result in the loss of lives and aircraft. The potential for an in-flight medical event deserves the attention of certification authorities.

A Pilot Randomized Controlled Trial Testing the Effectiveness of a Pedestrian Training Program That Teaches Children Where and How to Cross the Street Safely

Objective Pedestrian injury is a leading cause of injury-related mortality for children. This pilot randomized controlled trial tested the efficacy of a training program to teach where and how to cross safely.

A New Online Mental Health Training Program for Workplace Managers: Pre-Post Pilot Study Assessing Feasibility, Usability, and Possible Effectiveness

Background Mental health has become the leading cause of sickness absence in high-income countries. Managers can play an important role in establishing mentally healthy workplaces and coordinating their organization’s re…

Physiological measures in participants with chronic fatigue syndrome, multiple sclerosis and healthy controls following repeated exercise: a pilot study

To compare physiological responses of chronic fatigue syndrome (CFS/ME), multiple sclerosis (MS) and healthy controls (HC) following a 24‐h repeated exercise test, a large number of subjects were randomly assigned to eit…

Handgrip fatiguing exercise can provide objective assessment of cancer-related fatigue: a pilot study

The handgrip maximal force, critical force, and force variability may offer objective measures of the different dimensions of cancer-related fatigue and could provide a complementary approach to the patient reported outc…

The Effect of Clown Intervention on Self-Report and Biomarker Measures of Stress and Fatigue in Pediatric Osteosarcoma Inpatients: A Pilot Study

Background: Pediatric cancer patients experience different psychological processes during hospitalization that may regulate the immune response and affect recovery and response to cancer treatment.

A Physical and Psychological Approach to Managing Fatigue in Myasthenia Gravis: A Pilot Study

Background Fatigue in myasthenia gravis (MG) is common and difficult to manage. Unlike myasthenic weakness it is not amenable to drug therapies.